Medical Pharmacology Chapter 27: Gastrointestinal Drugs
Pharmacological Management of Ulcer Disease
Other GI Drugs
Peptic ulcer: stomach or duodenal mucosal lesion WITH acid and pepsin playing major pathogenic roles.
Major causative factor:bacterium Helicobacter pylori
Helicobacter pylori: risk factor for:
Certain types of gastric lymphoma
Zollinger-Ellison syndrome (causative agent-gastrin-secreting islet cell tumor (gastrinoma)) -- considered a form of peptic ulcer
Caused by an imbalance between aggressive factors (mainly gastric acid and pepsin) and protective factors (mucosal defenses).
Friedman, L. S. and Peterson, W.L. Peptic Ulcer and Related Disorders In Harrison's Principles of Internal Medicine 14th edition, (Isselbacher, K.J., and Braunwald, E., Wilson, J.D., Martin, J.B., Fauci, A.S. and Kasper, D.L., eds) McGraw-Hill, Inc (Health Professions Division), 1998, pp. 1597-1616.