• Acute Leukemia

  • Leukemia

• Hodgkin's Disease

• non-Hodgkin's Lymphoma

• Multiple Myeloma

• Chronic Lymphocytic Leukemia

• Chronic Myelogenous Leukemia

• Acute myelocytic and myelomonocytic leukemia

• Lung Carcinoma

• Head and Neck Carcinoma

• Endometrial Carcinoma

• Ovarian Carcinoma

• Cervical Carcinoma

• Breast Carcinoma

• Choriocarcinoma

• Polycythemia Vera

• Testicular Carcinoma

• Prostatic Carcinoma

• Wilms Tumor

• Neuroblastoma

• Thyroid Carcinoma

• Adrenal Carcinoma

• Stomach or Pancreatic Carcinoma

• Colon Cancer

• Carcinoid

  • Carcinoid II

• Insulinoma

• Osteogenic Sarcoma

• Melanoma

• Acute leukemia/lymphoma:

  • Primary drugs:

    • Induction:

      • Vincristine plus prednisone

    •  Remission maintenance (combination of drugs below):

      • Mercaptopurine (Purinethol)

      • Methotrexate

      • Cyclophosphamide (Cytoxan)

  • Other useful drugs/modalities:

    • Asparaginase (El-spar)

    • Daunorubicin (DaunoXome)

    • Carmustine (BNCU,BiCNU)

    • Cytarabine (ARA-C)

    • Allopurinol (Zyloprim, Purinol)-- supportive agent; xanthine oxidase inhibitor (reduces hyperuricemia)

    • Spinal radiotherapy

• Hodgkin's Disease: (stages III and IV)

  • Primary Drugs:

    • Combination chemotherapy:

      •  Vinblastine (Velban)

      •  Doxorubicin (Adriamycin)

      •  Dacarbazine (DTIC)

      •  Bleomycin (Blenoxane)

  • Other useful drugs/modalities:

    • Lomustine (CCNU,CeeNU)  Rtoposide (VP-16,VePe-sid)  Ifofamide (Ifex)  Interferon

      Mechlorethamine (Mustargen)  Vincristine (Oncovin)  Procarbazine (Matulane)  Prednisone (Deltasone)

• Non-Hodgkin's lymphoma:

  • Primary drugs:

    • Combination therapy:

      • Cyclophosphamide (Cytoxan)

      • Doxorubicin (Adriamycin)

      • Vincristine (Oncovin)

      • Prednisone (Deltasone)

    • Other useful drugs/modalities:

      • Stem cells transplantation

      • Monoclonal antibody treatment (investigational)

      • Cytokine therapy (interleukin 12) (investigational)

      • Vaccination

        • Bleomycin (Blenoxane) Lomustine (CCNU,CeeNU) Carmustine (BNCU,BiCNU) Etoposide (VP-16,VePe-sid)

          Interferon Mitoxantrone (Novantrone) Ifofamide (Ifex)

         

• Multiple Myeloma:

  • Primary drugs:

    •  Melphalan (Alkeran)plus prednisone (Deltasone)

    • Combination therapy

  • Other useful drugs/modalities:

    • Cyclophosphamide (Cytoxan)

    • Vincristine (Oncovin)

    • Carmustine (BNCU,BiCNU)

    • Interferon

    • Doxorubicin (Adriamycin)

  Chronic lymphocytic leukemia

  • Primary drugs:

    • Chlorambucil (Leukeran) and prednisone (Deltasone)(if indicated)

    • Fludarabine (Fludara)

  • Other useful drug/modalities:

    • Chlorambucil (Leukeran) and prednisone (Deltasone)

    • Allopurinol (Zyloprim, Purinol)-- supportive agent; xanthine oxidase inhibitor (reduces hyperuricemia)

    • Doxorubicin (Adriamycin)

    • Cladribine (Leustatin)

  Chronic myelogenous leukemia

  • Primary drugs:

    • Busulfan (Myleran) or interferon

    • Allogenic bone marrow transplantation (certain patients)

  • Other useful drugs/modalities:

    • Vincristine (Oncovin)

    • Mercaptopurine (Purinethol)

    • Hydroxyurea (Hydrea)

    • Melphalan (Alkeran)

    • Interferon

    • Allopurinol (Zyloprim, Purinol)-- supportive agent; xanthine oxidase inhibitor (reduces hyperuricemia)

• Acute myelocytic and myelomonocytic leukemia:

  • Primary drugs:

    •  Combination Therapy:cytarabine (ARA-C) and

      •  Mitoxantrone (Novantrone) or

      •  Daunorubicin (DaunoXome) or

      •  Idarubicin (Idamycin)

  • Other useful drugs/modalities:

    • Methotrexate

    • Thioguanine

    • Mercaptopurine (Purinethol)

    • Allopurinol (Zyloprim, Purinol) -- supportive agent; xanthine oxidase inhibitor (reduces hyperuricemia)

    • Mitoxantrone (Novantrone)

    • Etoposide (VP-16,VePe-sid)

    • Azacitidine

    • Amsacrine

  Lung carcinoma:

  • Primary drugs:

    • Etoposide (VP-16,VePe-sid) plus cisplatin (Platinol), vinorelbine (Navelbine)

  • Other useful drugs/modalities:

    • Methotrexate

    • Vincristine (Oncovin)

    • Vinblastine (Velban)

    • Doxorubicin (Adriamycin)

    • Mitomycin (Mutamycin)

  Head and Neck carcinoma:

  • Primary drugs:

    • Fluorouracil (5-FU) plus cisplatin (Platinol)

  • Other useful drugs/modalities:

    • Methotrexate

    • Bleomycin (Blenoxane)

    • Hydroxyurea (Hydrea)

    • Daunorubicin (DaunoXome)

    • Vincristine (Oncovin)

    • Vinorelbine (Navelbine)

Salmon, S. E. and Sartorelli, A. C. Cancer Chemotherapy, in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, pp 903-904 (adapted from table 55-7)