• Endometrial carcinoma:

  • Primary drugs:

    • Progestins or tamoxifen (Nolvadex)

  • Other useful drugs/modalities:

    • Doxorubicin (Adriamycin)

    • Cisplatin (Platinol)

    • Carboplatin (Paraplatin) 

• Ovarian cancer:

  • Primary drugs:

    • Cisplatin (Platinol)

    • Carboplatin (Paraplatin)

  • Other useful drugs/modalities:

    • Cyclophosphamide (Cytoxan)  Carboplatin (Paraplatin)  Doxorubicin (Adriamycin)  Melphalan (Alkeran)

      Flurouracil (5-FU)  Vincristine (Oncovin)  Altretamine (Hexalen)  Bleomycin (Blenoxane)

• Cervical cancer:

  • Primary drugs:

    • Cisplatin (Platinol)

    • Carboplatin (Paraplatin)

  • Other useful drugs/modalities:

    • Lomustine (CCNU,CeeNU)  Lyclophosphamide (Cytoxan)  Doxorubicin (Adriamycin)  Methotrexate  Mitomycin (Mutamycin)

      Bleomycin (Blenoxane)   Vincristine (Oncovin)  Interferon   13-cis-Retinoic acid

• Breast cancer:

  • Primary drugs:

    • Adjuvant chemotherapy or tamoxifen following surgery

    • Combination chemotherapy or hormonal medication for late recurrence

  • Other useful drugs/modalities:

    • Cyclophosphamide (Cytoxan)  Doxorubicin (Adriamycin)  Vincristine (Oncovin)  Methotrexate  Flurouracil (5-FU)

      Paclitaxel (Taxol)  Mitoxantrone (Novantrone)  Prednisone (Deltasone)  Aminoglutethimide  Megestrol  Androgens

• Choriocarcinoma (trophoblastic neoplasm)

  • Primary drugs:

    • Methotrexate

    • Etoposide (VP-16,VePe-sid) plus cisplatin (Platinol)

  • Other useful drugs/modalities:

    • Vinblastine (Velban)

    • Mercaptopurine (Purinethol)

    • Chlorambucil (Leukeran)

    • Doxorubicin (Adriamycin)

  Polycythemia vera

  • Primary drugs:

    • Busulfan (Myleran)

    • Chlorambucil (Leukeran)

    • Cyclophosphamide (Cytoxan)

  • Other useful drugs/modalities:

    • Radioactive P³²

  Testicular cancer:

  • Primary drugs:

    • Combination chemotherapy:

      •  Cisplatin (Platinol)

      •  Bleomycin (Blenoxane)

      •  Etoposide (VP-16,VePe-sid)

  • Other useful drugs/modalities:

    • Methotrexate  Dactinomycin (Cosmegen)  Plicamycin (Mithramycin)  Vinblastine (Velban)

      Doxorubicin (Adriamycin)  Cyclophosphamide (Cytoxan)  Etoposide (VP-16,VePe-sid)

• Prostatic cancer:

  • Primary drugs:

    • Estrogens

    • GnRH agonist plus flutamide (Eulexin)

  • Other useful drugs/modalities:

    • Aminoglutethimide  Doxorubicin (Adriamycin)  Cisplatin (Platinol)  Prednisone (Deltasone)

      Estramustine (Emcyf)   Flurouracil (5-FU)   Progestins

• Wilms' tumor:

  • Primary drugs:

    • Vincristine (Oncovin) plus dactinomycin (Cosmegen) (after surgery and radiation treatment)

  • Other useful drugs/modalities:

    • Methotrexate

    • Cyclophosphamide (Cytoxan)

    • Doxorubicin (Adriamycin)

• Neuroblastoma:

  • Primary drugs:

    • Cyclophosphamide (Cytoxan) plus doxorubicin (Adriamycin) plus vincristine (Oncovin)

  • Other useful drugs/modalities:

    • Dactinomycin (Cosmegen)

    • Daunorubicin (DaunoXome)

    • Cisplatin (Platinol)

  Thyroid cancer:

  • Primary drugs:

    • Radioiodine (I¹³¹)

    • Doxorubicin (Adriamycin)

    • Cisplatin (Platinol)

  • Other useful drugs/modalities:

    • Bleomycin (Blenoxane)

    • Flurouracil (5-FU)

    • Melphalan (Alkeran)

  Adrenal carcinoma:

  • Primary drug:

    •  Mitotane (Lysodren)

  Stomach or pancreatic carcinoma:

  • Primary drugs:

    • FLurouracil (5-FU) plus doxorubicin (Adriamycin), mitomycin (Mutamycin)

  • Other useful drugs/modalities:

    • Hydroxyurea (Hydrea)

    • Lomustine (CCNU,CeeNU)

    • Cisplatin (Platinol)

  Colon cancer:

  • Primary drugs:

    • Flurouracil (5-FU) plus leucovorin or interferon (or both)

  • Other useful drugs/modalities:

    • Cyclophosphamide (Cytoxan)

    • Mitomycin (Mutamycin)

    • Nitrosoureas

  Carcinoid:

  • Primary drugs:

    • Doxorubicin (Adriamycin) + cyclophosphamide (Cytoxan)

    • Fluorouracil (5-FU)

    • Octreotide

  • Other useful drugs/modalities:

    • Interferon

    • Dactinomycin (Cosmegen)

    • Streptozocin (Zanosar)

    • Methysergide (Sansert) (supportive therapy)

  Insulinoma:

  • Primary drugs:

    • Streptozocin (Zanosar)

    • Interferon

  • Other useful drugs/modalities:

    • Doxorubicin (Adriamycin)

    • Fluorouracil (5-FU)

    • Mitomycin (Mutamycin)

    • Streptozocin (Zanosar)

  Osteogenic sarcoma:

  • Primary drugs:

    • Doxorubicin (Adriamycin)

    • Methotrexate with citrovorum rescue after surgery

  • Other useful drugs/modalities:

    • Cyclophosphamide (Cytoxan)

    • Dacarbazine (DTIC)

    • Interferon

    • Ifofamide (Ifex)

  Melanoma:

  • Primary drugs:

    • Dacarbazine (DTIC)

    • Cisplatin (Platinol)

  • Other useful drugs/modalities:

    • Lomustine (CCNU,CeeNU)

    • Hydroxyurea (Hydrea)

    • Mitomycin (Mutamycin)

    • Dactinomycin (Cosmegen)

    • Interferon

    • Tamoxifen (Nolvadex)

Salmon, S. E. and Sartorelli, A. C. Cancer Chemotherapy, in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, pp 903-904 (adapted from table 55-7)